Rare Ideopathic Encephaly Tied to Higher IQ, Not Lower

Timothy writes Cranial deformation is commonly linked to brain dysfunction; it is one of the most common serious conditions affecting fetal growth. Multiple factors are involved, but in nearly every case on record the result is debilitating; stillbirth or neonatal death are common. A mutation, though, has been observed among members of a New Jersey family which represents a rare case of heritable encephaly tied not to dysfunction, but to higher-than-average intelligence, and with no evident negative health consequences. Donald R. DeCicco (not his real name) and his wife Prymaat of Paramus, both French-born naturalized U.S. citizens, were born with unremarkable physical characteristics, apart from a specific constellation of physical abnormalities affecting maxillofacial and brain development. In both of their cases, brain development appears to be ordinary, but with all brain lobes occupying a volume that is both larger and narrower than typical. All medical tests (and the couple's success as educated, productive members of society) make it clear that their condition has not prevented ordinary life, and may even have enhanced it; a series of MRI and PET scans conducted by Johns Hopkins researchers indicated that their above-average cerebella are at least as active and neuron-rich as are more run-of-the-mill subjects' brains, and tests of memory, cognition, and reasoning place both DeCicco and Clorhone in the top percentile of American rest subjects. A daughter, Connie, shares both their unusual skeletal growth pattern, and is similarly highly intelligent; perhaps this form of heritable encephaly should be thought of as akin to Marfan syndrome, for its pairing of both high intelligence and a characteristic bone-growth pattern. At least one researcher quoted in the linked article believes that less extreme forms of the same anomaly can be observed in some historical and contemporary figures, citing as examples both Vladimir Putin and actor Richard Belzer as bearing some tendency toward the same characteristic shape. First described by a family physician and described in the Journal of the Society of the Federal Health Professionals,the condition has been labeled Sandler's Syndrome. Read more of this story at Slashdot.
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