In the early 1900s, an Irish cook named Mary Mallon made the rounds in New York City, cooking for various wealthy families.She left a wave of infection in her wake.Scientists eventually discovered that she was a healthy carrier of typhoid fever, meaning that she carried the bacteria that causes typhoid but showed no outward symptoms.Mallon became immortalized as Typhoid Mary, a nickname that came to symbolize the spread of disease.Typhoid Mary was a very tolerant host who unfortunately also shed tons of pathogen, said David Schneider, an immunologist at Stanford University.Given striking cases like Mallons, why did it take so long for immunologists to turn their attention to tolerance'When Mallons case came to light, the field of immunology was poised for a revolution. In 1928, Alexander Flemingdiscovered penicillin, the first true antibiotic. Along with the growing use ofvaccines, these drugs would change the face of medicine, rendering previously deadly infections treatable or largely eradicating them altogether.That sea change drove much of modern immunology research. Captivated by the overwhelming success of vaccination and antimicrobial drugs, immunologists focused on how the immune system recognizes foreign invaders. We thought the only way to get rid of pathogens was through elimination, either by the immune system or with antimicrobial drugs, saidMiguel Soares, an immunologist at the Gulbenkian Institute of Science in Portugal. We didnt realize there is a second layer of protection, that cells and organs can adapt to pathogens without dysfunction.Plant scientists, on the other hand, have been studying tolerance for decades. Plants vary in how they respond to pathogens, some growing well despite serious infections. The concept has begun to take root in the animal immunology world over the last 10 years or so. We knew it happened but didnt have a systematic way of describing this process, Soares said.Of course, the mechanisms that Soares and others have called tolerance arent entirely new to immunology. Scientists have been studying something called the cellular stress response for decades. Environmental stressors, like high temperatures, trigger a set of molecular changes that help protect the cell from damage. This is indeed a tolerance mechanism, Soares said.More than a century after Mary Mallons notoriety, scientists still dont know exactly how the cook kept her typhoid at bay. (Her tolerance of typhoid isnt that rareroughly 1 to 6 percent of people infected with Salmonellabacteria, the microbes that cause typhoid, become simply carriers.) But Stanford University scientists have some ideas. They found that microbes could take up residence in the immune cells that should be attacking them. The bacteria take advantage of the fact that these normally ferocious immune cells, known as macrophages, enter a more hospitable state after the initial stages of infection. The infected cells then hide out in the lymph nodes of the gut and spleen.SEE ALSO:An ancient disease is killing thousands of people every day ' and it could become more common in the USJoin the conversation about this storyNOW WATCH: The deadliest disease known to humans has been killing us for over 20 million years
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