Certain jobs dads do linked to higher birth defects' risk

SEVERAL types of job carried out by future fathers may be linked to an increased risk of birth defects in their babies, suggests research published online in Occupational and Environmental Medicine.Previous research has linked certain occupations with a higher risk of birth defects in offspring, but it has tended to lump together very different types of defects and occupations, in order to achieve large sample sizes, with the attendant potential to skew the results, say the authors.They based their findings on data from the ongoing United States (U.S.) National Birth Defects Prevention Study, which is investigating a range of potential risk factors for major birth defects in a large population sample.They obtained the job histories of just under 1000 dads who had had a child with one or more birth defects born between 1997 and 2004, and those of just over 4000 dads whose kids did not have congenital abnormalities, via telephone interviews with their partners.This included defects among stillborn babies and those that were aborted, as well as in live born children. Jobs were then classified into 63 groups, based on assumed exposure profiles to chemicals or other potential hazards within the job itself and within the profession/industry.Job classification was restricted to the three months before conception and the first month of pregnancy, considered to be the critical period for susceptibility to damage passed on in the father's sperm.Particular mathematical methods were used (Bayesian analysis) to take account of the statistical difficulties associated with analysing small sample sizes in numerous categories of risk exposure and more than 60 different categories of birth defect.Most (90 per cent) of the dads had had only one job during this four-month period. The most common groups of jobs were those in management/admin, sales and the construction industry.Their analyses showed that nearly a third of job types were not associated with any increased risk of birth defects.These included architects and designers, healthcare professionals, dentists, firefighters, fishermen, car assembly workers, entertainers, smelters and foundry workers, stonemasons and glass blowers/cutters, painters, train drivers/maintenance engineers, soldiers, commercial divers.But certain types of jobs seemed to be associated with an increased risk of having a child with a birth defect in three or more categories.
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